Missile attacks on Aleppo have enraged the oppositionThe main Syrian opposition alliance will not attend a series of meetings in protest at what it said was the international community's "shameful" failure to stop violence.
The National Coalition said it had decided not to attend a summit of the Friends of Syria in Rome next month.
It was also turning down invitations for talks in Washington and Moscow.
A statement singled out Russia for supporting and supplying weapons to President Bashar al-Assad.
"The international silence on the crimes committed every day against our people amounts to participating in two years of killings," the National Coalition said.
"The Russian leadership especially bears moral and political responsif readiness to step down, our correspondent adds.
In Syria on Saturday, the battle for control of Aleppo's international airport reportedly intensified.
The Syrian Observatory for Human Rights, a UK-based activist group, said the fighting between government forces and rebel fighters was focused on a section of motorway linking the airport to the city, which has been used by the military to transport troops and supplies.
The fighting comes a day after troops were accused of firing missiles into a rebel-held district in Aleppo's east, killing at least 31 people.
The UN special envoy to Syria, Lakhdar Brahimi, meanwhile described the car bomb attack on the ruling Baath Party's headquarters in Damascus on Thursday as a war crime. He said it left about 100 people dead.
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